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M U Ngy nay vi tc pht trin nhanh chng ca khoa hc k thut, cng ngh bo ch thuc cng khng ngng c nhng bc t ph mi c v s lng cng nh cht lng. Cng vi xu th hi nhp th gii, Vit Nam cc ch phm thuc c bn chuyn gim au, h st, khng vim cng c sn xut rt a dng, thnh phn khng ch cha cc dc cht c hot tnh m cn cha nhiu loi t dc nhm tng hiu qu iu tr. Dc phm l mt loi hng ha c bit nn khu kim nghim cht lng thuc tr nn ht sc quan trng; iu ny em li cho ngi bnh hiu qu v an ton.

Trn th trng hin nay, cc ch phm trong v ngoi nc c tc dng iu tr cc bnh thng thng nh cm cm, nhc u, gim au, khng vim, h st thng c thnh phn chnh l Paracetamol, Ibuprofen v Caffein. V th nhu cu phn tch nh tnh cng nh nh lng cc dc cht ny rt c quan tm. Vit Nam, cc nh phn tch nghin cu ng dng nhiu phng php phn tch hin i nh trc quang, in di mao qun, sc k lng, sc k kh xy dng quy trnh phn tch cho mi loi dc phm khc nhau.

Trn xu hng , nhiu cng trnh nghin cu nh tnh v nh lng Paracetamol, Ibuprofen v Caffein trong cc loi dc phm c thc hin. Trong dc in M USP30 United State Pharmacy , phng php sc k lng hiu nng cao vit tt l HPLC l phng php c quy nh cho php nh lng ng thi Paracetamol v Ibuprofen trong cc ch phm hai thnh phn c cha ng thi hai dc cht ny cng nh cc ch phm mt thnh phn ch cha Paracetamol hoc Ibuprofen.

Tuy nhin nhng nghin cu ng dng phng php HPLC phn tch cc dc phm c cha hai thnh phn ny cn hn ch, cha c nghin cu su. H Ch Minh, chng ti quyt nh chn ti: Xc nh ng thi Paracetamol v Ibuprofen trong cc dc phm bng phng php sc k lng hiu nng cao HPLC nghin cu xy dng quy trnh phn tch cc mu dc phm c cha Paracetamol hoc Ibuprofen hoc cha c hai thnh phn.

Nhit nng chy: C F. Paracetamol l mt cht khng mi, c v hi ng, tinh th dng bt mu trng. N ha tan trong cc dung mi hu c nh methanol v ethanol nhng t tan trong nc v ether. Dc tnh Paracetamol l thuc gim au, h st nhng c tc dng chng vim nh aspirin.

So vi cc loi thuc khc, Paracetamol t c tc dng ph theo liu iu tr v c php bn khng cn k n. Y t Th gii, c bit n nh mt loi thuc chng vim dng liu thp nhng c hiu qu cao trong iu tr. Trang 3. Tnh cht vt l v ha hc Ibuprofen tn ti dng bt kt tinh khng mu, c mi c bit.

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